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Joel M. Harp , Ph.D.

Research Assistant Professor of Biochemistry
Adjunct Assistant Professor of Biological Sciences

Abstracts from PubMed

results for: Joel Harp Vanderbilt

Harp, JM, Guenther, DC, Bisbe, A, Perkins, L, Matsuda, S, Bommineni, GR, Zlatev, I, Foster, DJ, Taneja, N, Charisse, K, Maier, MA, Rajeev, KG, Manoharan, M, Egli, M Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Abe, M, Seto, M, Gogliotti, RG, Loch, MT, Bollinger, KA, Chang, S, Engelberg, EM, Luscombe, VB, Harp, JM, Bubser, M, Engers, DW, Jones, CK, Rodriguez, AL, Blobaum, AL, Conn, PJ, Niswender, CM, Lindsley, CW Discovery of VU6005649, a CNS Penetrant mGlu Receptor PAM Derived from a Series of Pyrazolo[1,5-]pyrimidines
Malek-Adamian, E, Guenther, DC, Matsuda, S, Martínez-Montero, S, Zlatev, I, Harp, J, Burai Patrascu, M, Foster, DJ, Fakhoury, J, Perkins, L, Moitessier, N, Manoharan, RM, Taneja, N, Bisbe, A, Charisse, K, Maier, M, Rajeev, KG, Egli, M, Manoharan, M, Damha, MJ 4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Archuleta, TL, Frazier, MN, Monken, AE, Kendall, AK, Harp, J, McCoy, AJ, Creanza, N, Jackson, LP Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin
Schlegel, MK, Foster, DJ, Kel'in, AV, Zlatev, I, Bisbe, A, Jayaraman, M, Lackey, JG, Rajeev, KG, Charissé, K, Harp, J, Pallan, PS, Maier, MA, Egli, M, Manoharan, M Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
Tang, D, Li, J, Buck, JR, Tantawy, MN, Xia, Y, Harp, JM, Nickels, ML, Meiler, J, Manning, HC Evaluation of TSPO PET Ligands [F]VUIIS1009A and [F]VUIIS1009B: Tracers for Cancer Imaging
Kel'in, AV, Zlatev, I, Harp, J, Jayaraman, M, Bisbe, A, O'Shea, J, Taneja, N, Manoharan, RM, Khan, S, Charisse, K, Maier, MA, Egli, M, Rajeev, KG, Manoharan, M Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides
Jeffries, DE, Witt, JO, McCollum, AL, Temple, KJ, Hurtado, MA, Harp, JM, Blobaum, AL, Lindsley, CW, Hopkins, CR Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (DR) antagonists
Thompson, MK, Keithly, ME, Goodman, MC, Hammer, ND, Cook, PD, Jagessar, KL, Harp, J, Skaar, EP, Armstrong, RN Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus
Uddin, MI, Buck, JR, Schulte, ML, Tang, D, Saleh, SA, Cheung, YY, Harp, J, Manning, HC Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes
Gentry, PR, Kokubo, M, Bridges, TM, Kett, NR, Harp, JM, Cho, HP, Smith, E, Chase, P, Hodder, PS, Niswender, CM, Daniels, JS, Conn, PJ, Wood, MR, Lindsley, CW Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Thompson, MK, Keithly, ME, Harp, J, Cook, PD, Jagessar, KL, Sulikowski, GA, Armstrong, RN Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus
Schulte, ML, Turlington, ML, Phatak, SS, Harp, JM, Stauffer, SR, Lindsley, CW Total synthesis of stemaphylline N-oxide and related C9a-epimeric analogues
Tang, D, McKinley, ET, Hight, MR, Uddin, MI, Harp, JM, Fu, A, Nickels, ML, Buck, JR, Manning, HC Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging
Patra, A, Harp, J, Pallan, PS, Zhao, L, Abramov, M, Herdewijn, P, Egli, M Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs
Fortenberry, C, Bowman, EA, Proffitt, W, Dorr, B, Combs, S, Harp, J, Mizoue, L, Meiler, J Exploring symmetry as an avenue to the computational design of large protein domains
Morin, A, Kaufmann, KW, Fortenberry, C, Harp, JM, Mizoue, LS, Meiler, J Computational design of an endo-1,4-beta-xylanase ligand binding site
Stourman, NV, Branch, MC, Schaab, MR, Harp, JM, Ladner, JE, Armstrong, RN Structure and function of YghU, a nu-class glutathione transferase related to YfcG from Escherichia coli