Dean of Graduate Education and Research, College of Arts & Science
Stevenson Professor of Chemistry
Dr. McLean is currently accepting graduate students for Fall 2024 - APPLY TODAY
The McLean group research activities center around the development and application of advanced mass spectrometry technologies for structural and molecular scale measurements, primarily via ion mobility-mass spectrometry (IM-MS). IM-MS is an integrated, two-dimensional analytical technique that provides rapid (µs-ms) separations based on molecular size and mass. Our focus is on using IM-MS with other analytical separation dimensions (e.g., liquid chromatography, LC; and tandem MS) to perform broad-scale, untargeted measurements of individual molecules derived from biological origins, inclusive of metabolites, carbohydrates, lipids, peptides and proteins. This multidimensional mass spectrometry approach provides a comprehensive inventory of the individual molecules present within a given sample, which can be further interrogated on a per-dimension level to obtain specific molecular information. For example, chemical hydrophobicity from LC, gas-phase size from IM; intrinsic mass from MS; and the connectivity of chemical bonds and function groups from tandem MS/MS. The elegance of this multidimensional MS approach is that all physiochemical properties can be obtained on a single measurement from microliters of sample, providing a basis for the rapid interrogation of large sample libraries to yield both a broad and deep chemical understanding at the systems biology level.