Brian O. Bachmann
Stevenson Professor of Chemistry
We study and harness the biosynthetic capabilities of living systems in order to radically accelerate the discovery of new bioactive compounds, and revolutionize how molecules are synthesized.
The vision of the VLBS is threefold: (1) Developing and applying single cell chemical biology techniques, we will unlock the potential of natural products for precision medicine for cancer; (2) Understanding the biosynthesis of biologically active natural products will enable us to engineer new natural products that will become the next generation of drugs to treat human illnesses; (3) Revealing and understanding the evolutionary mechanisms for how nature evolves bioactive natural products, we will develop new paradigms for the construction of biosynthetic pathways for compounds that are not natural products but should be, thereby transforming what are now costly and waste-generating chemical synthetic processes in to ‘green’ and inexpensive processes. These visions are reflected in our projects incorporating methods in biochemistry, human cell biology, chemical synthesis, and microbiology.