Andrea Locke

Assistant Professor of Chemistry & Biomedical Engineering

The Locke Biosensing Lab develops novel optical biosensing platforms to address current clinical diagnostic challenges at the point of care. We explore the use of various nanoplasmonic structures incorporated in paper- or micro-fluidic platforms to create rapid diagnostic platforms that are simplistic and user-friendly. Current projects use surface-enhanced Raman spectroscopy and localized surface plasmon resonance to detect pathogens and other bioanalytes in various biological fluids derived from clinical samples.

Specializations

Analytical Chemistry, Optical Spectroscopy, Biosensor

Representative Publications

https://orcid.org/0000-0002-7357-9688

Locke, A.+, Zaki, F. R.+, Fitzgerald, S. T., Sudhir, K., Monroy, G. L., Choi, H., Won, J., Mahadevan- Jansen, A., and Boppart, S. A. Differentiation of otitis media-causing bacteria and biofilms via Raman spectroscopy and optical coherence tomography. Frontiers in Cellular and Infection Microbiology: Clinical Microbiology. 2022;12, 1051.PMID: 36034696. PMCID: PMC9400059

Rourke, A. S.; Walter, A.; Carroll, B.; Mahadevan-Jansen, A.; Locke, A.K. In A novel paper-based substrate for coffee ring augmented surface-enhanced Raman spectroscopy, Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics, SPIE: 2022; p PC1196802.

Locke, A.K.+; Hiremath, G.+; Thomas, G.; Gautam, R.; Acra, S.; Correa, H.; Dellon, E.S.; Mahadevan- Jansen, A. Novel Insights Into Tissue-specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy. 2020; 11 (7): e00195. PMID: 32764208. PMCID: PMC7386346.

Locke A, Fitzgerald S, Mahadevan-Jansen A. Advances in Optical Detection of Human-Associated Pathogenic Bacteria. Molecules. 2020; 25(22): 5256. PMID: 33187331. PMCID: PMC7696695.