Alex Schuppe
Assistant Professor of Chemistry
Dr. Schuppe will be accepting graduate students for Fall 2025.
We are a synthetic organic chemistry group focused on tackling long-standing synthetic challenges and discovering empowering transition-metal-catalyzed coupling protocols to expand chemical space that can be accessed from abundant precursors.
Central to our research interests is the desire to develop new carbon–carbon bond forming reactions to rapidly synthesize biologically active small molecules. We are particularly interested in designing innovative strategies to access molecules with potent anticancer and neurological activities. Utilizing state-of-the-art resources available at Vanderbilt, including the High-Throughput Screening (HTS) facility, we will rapidly interrogate the biological activity of the molecules we synthesize.
Researchers in the group will gain expertise in asymmetric catalysis, organometallic chemistry, and multi-step synthesis.
Specializations
| Organic, Catalysis, Total Synthesis |
Representative Publications
ORCID: 0000-0001-6002-9110
1. Schuppe, A. W.; Borrajo-Calleja, G. M.; Buchwald, S. L. Enantioselective Olefin Hydrocyanation without Cyanide. J. Am. Chem. Soc. 2019,141,18668–18672.
2. Schuppe, A. W.; Knippel, J. L.; Borrajo-Calleja, G. M.; Buchwald, S. L. Enantioselective Hydroalkenylation of Olefins with Enol Sulfonates Enabled by Dual Copper Hydride and Palladium Catalysis. J. Am. Chem. Soc. 2021,143, 5330−5335.
3. Schuppe, A. W.; Huang, D.; Chen, Y.; Newhouse, T. R. Total Synthesis of (–)-Xylogranatopyridine B via a Palladium-Catalyzed Oxidative Stannylation of Enones. J. Am. Chem. Soc. 2018,140, 2062–2066.