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Brandt F. Eichman, Ph.D.

William R. Kenan, Jr. Chair
Professor and Chair of Biological Sciences
Professor of Biochemistry

Research in Professor Eichman’s laboratory focuses on understanding protein machines involved in maintenance of genome integrity, using structural biology to determine atomic structures of DNA repair enzymes. Current projects in the Eichman lab focus on base excision repair of interstrand DNA crosslinks and damage and restart of stalled replication forks during the DNA damage response. As an undergraduate, Eichman trained as a synthetic organic chemist, and in graduate school he used X-ray crystallography to study the effects of anti-cancer agents on DNA structure and determined the landmark structure of the Holliday junction—the four-stranded DNA intermediate formed during genetic recombination. As an NIH postdoctoral fellow at Harvard Medical School, Eichman studied the structural enzymology of DNA repair and replication proteins. He is currently Professor and Chair of the Department of Biological Sciences, Professor of Biochemistry, and holds the William R. Kenan, Jr. Chair at the College of Arts and Science. Professor Eichman teaches introductory and advanced undergraduate and graduate biochemistry courses and co-founded the Vanderbilt Undergraduate Program in Biochemistry and Chemical Biology.