Mintu Chandra

Research Assistant Professor in Biological Sciences
Jackson Lab

Research Focus and Interests: Dr. Chandra's research centers on the spatiotemporal regulation of membrane trafficking, with a particular emphasis on understanding how protein-lipid interactions govern this process. By integrating protein structural data with biophysical, biochemical, and cellular methodologies, his work aims to elucidate the complex roles of proteins in human health and disease.

Current Research Directions: Recognizing the pivotal role of endosomal trafficking in neurodegenerative diseases and cancers, Dr. Chandra has directed his research towards this critical area. Using cutting-edge structural biology techniques: cryoEM/cryoET, biophysical assays, and cellular studies, his research focus on understanding the structural and functional aspects of Retromer and Sorting Nexin proteins, aiming to uncover how their mutations and dysregulation contribute to such diseases.

Implications of Research: By leveraging structural insights, Dr. Chandra aims to design small molecule inhibitors or stabilizers targeting active sites, offering potential therapeutic strategies for conditions like Alzheimer's, Parkinson's, and various cancers. His research not only enhances the fundamental understanding of cellular processes but also identifies novel targets for therapeutic intervention, addressing significant global health challenges.