10/18/2024 Eli Sennesh: Predictability Modulates, but does not override, Stimulus History in Oddball Processing
Neuroscience Brown Bag
Eli Sennesh, PhD
Post-Doctoral Fellow, Bastos Lab
Date: Friday, October 18, 2024
Time: 1:25PM-2:15PM
Location: 316 Wilson Hall
Predictability Modulates, but does not override, Stimulus History in Oddball Processing
Predictive coding hypothesizes evoked, feedforward responses in a canonical cortical microcircuit that depend on stimulus probability, not content. However, previous experiments considered changes of stimulus content with probability, potentially confounding predictive coding with neuronal adaptation. As part of the OpenScope project, the Allen Institute recorded high-density laminar electrophysiology in six areas of the brain as N=14 mice performed a passive Global-Local Oddball (GLO) task. Current-source density and statistical analyses show that against the hypotheses of predictive coding, “oddball” responses appear only as a result of stimulus change and stimulus history, while stimulus probability serves to significantly modulate responses when stimulus history is held constant.
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