{"id":2065,"date":"2025-12-01T20:08:55","date_gmt":"2025-12-01T20:08:55","guid":{"rendered":"https:\/\/as.vanderbilt.edu\/psychology\/?p=2065"},"modified":"2025-12-08T17:43:18","modified_gmt":"2025-12-08T17:43:18","slug":"12-5-25-valentina-cigliola-innate-mechanisms-of-spinal-cord-regeneration","status":"publish","type":"post","link":"https:\/\/as.vanderbilt.edu\/psychology\/2025\/12\/01\/12-5-25-valentina-cigliola-innate-mechanisms-of-spinal-cord-regeneration\/","title":{"rendered":"12\/5\/25 Valentina Cigliola: Innate Mechanisms of Spinal Cord Regeneration"},"content":{"rendered":"<h4>Neuroscience brown bag<\/h4>\n<p><img loading=\"lazy\" class=\" wp-image-2284 alignleft\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-cas\/wp-content\/uploads\/sites\/58\/2025\/12\/01200835\/Screenshot-2025-12-01-090620-289x300.png\" alt=\"\" width=\"220\" height=\"228\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-cas\/wp-content\/uploads\/sites\/58\/2025\/12\/01200835\/Screenshot-2025-12-01-090620-289x300.png 289w, https:\/\/cdn.vanderbilt.edu\/vu-cas\/wp-content\/uploads\/sites\/58\/2025\/12\/01200835\/Screenshot-2025-12-01-090620.png 409w\" sizes=\"(max-width: 220px) 100vw, 220px\" \/>Valentina Cigliola, PhD<\/p>\n<p>Assistant Professor, Pharmacology<\/p>\n<p><strong>Date:<\/strong> Friday, December 5, 2025<\/p>\n<p><strong>Time:<\/strong> 1:25- 2:15<\/p>\n<p><strong>Location:<\/strong> 316 Wilson Hall<\/p>\n<h6><span data-olk-copy-source=\"MessageBody\">Innate Mechanisms of Spinal Cord Regeneration<\/span><\/h6>\n<p><span data-olk-copy-source=\"MessageBody\">Adult mammals including humans fail to regenerate the spinal cord after injury, leading to sensorimotor deficits and paralysis.\u00a0In contrast, zebrafish can fully regenerate and recover motor function after a complete spinal cord transection. This regenerative capacity relies on neurogenesis, formation of a glial and axonal bridge between the severed stumps, and restoration of synaptic circuits. I will discuss novel factors that trigger innate spinal cord regeneration and their underlying epigenetic regulation. I will also highlight how understanding mechanisms of innate regeneration in zebrafish can guide approaches to ultimately treat spinal cord injury in adult mammals.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neuroscience brown bag Valentina Cigliola, PhD Assistant Professor, Pharmacology Date: Friday, December 5, 2025 Time: 1:25- 2:15 Location: 316 Wilson Hall Innate Mechanisms of Spinal Cord Regeneration Adult mammals including humans fail to regenerate the spinal cord after injury, leading to sensorimotor deficits and paralysis.\u00a0In contrast, zebrafish can fully regenerate and recover motor function after&#8230;<\/p>\n","protected":false},"author":187,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[10],"tags":[],"acf":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/posts\/2065"}],"collection":[{"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/users\/187"}],"replies":[{"embeddable":true,"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/comments?post=2065"}],"version-history":[{"count":2,"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/posts\/2065\/revisions"}],"predecessor-version":[{"id":2286,"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/posts\/2065\/revisions\/2286"}],"wp:attachment":[{"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/media?parent=2065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/categories?post=2065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/as.vanderbilt.edu\/psychology\/wp-json\/wp\/v2\/tags?post=2065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}