11/11/25 Camille Archer: Interactive Effects of Phasic and Tonic Irritability and Negative Life Events on Internalizing Symptoms: Examining Network Connectivity
Clinical brown bag
Camille Archer
Graduate Student
Date: Tuesday, November 11, 2025
Time: 12:00- 1:00pm
Location: 316 Wilson Hall
Interactive Effects of Phasic and Tonic Irritability and Negative Life Events on Internalizing Symptoms: Examining Network Connectivity
This talk will present a proposed research project submitted for the NRSA. Internalizing disorders emerge early in development, underscoring the need to identify childhood risk factors that shape long-term outcomes. Irritability – both tonic (persistent grouchiness) and phasic (temper outbursts) – and exposure to negative life events are key predictors of internalizing symptoms, yet little is known about their distinct and interactive longitudinal effects or underlying neural mechanisms. This project will leverage data from the Adolescent Brain Cognitive Development (ABCD) Study, a cohort of over 11,000 youth followed from ages 9–15, with annual assessments of irritability, life events, and internalizing symptoms and biennial resting-state fMRI. Using linear mixed-effects models, Aim 1 will test how phasic and tonic irritability interact with negative life events to predict internalizing symptom trajectories. Aim 2 will use longitudinal canonical correlation analysis to examine how these irritability facets relate to network connectivity in the context of high negative life events. Findings will clarify whether tonic and phasic irritability confer distinct risk pathways and identify neural substrates that may drive divergent developmental outcomes.