Danial Asgari, a postdoctoral researcher in the Tate Lab, and Ann Tate, associate professor of Biological Sciences, recently published a study in Molecular Biology and Evolution titled “How the Structure of Signaling Regulation Evolves: Insights from an Evolutionary Model.” Their findings show that negative feedback loops (or NFLs) acting closer to a cell’s final decisions, such as turning genes on or off, are especially resistant to evolutionary change.