Examines the Role of Neuroinflammation in Aging and Neurodegeneration of the Retina, Specifically Glaucoma
Rebecca M. Sappington, Ph.D.
Department of Ophthalmology and Visual Sciences
Department of Pharmacology
Neuroscience Training Faculty
Vanderbilt University School of Medicine
My laboratory examines the role of neuroinflammation in aging and neurodegeneration of the retina, specifically glaucoma. Using a broad approach that encompasses behavioral, cellular and molecular neuroscience, we investigate the impact of glial cells and neuroinflammation, i.e. cytokine and chemokine production, on function and survival of retinal ganglion cells, whose axons form the optic nerve. Our goal is to identify potential targets for retinal therapeutics by understanding primary mechanisms of neuroinflammation.