Irish, Jonathan, Departments of Cell & Developmental Biology and Pathology, Microbiology, & Immunology

Jonathan Irish, Ph.D.
Assistant Professor
Department of Cell & Developmental Biology
Department of Pathology, Microbiology, & Immunology
Scientific Director, Cancer & Immunology Core (CIC)
Scientific Director, Mass Cytometry Center of Excellence (MCCE)
740B Preston Research Building
2220 Pierce Avenue
615-936-3460 (office)
jonathan.irish@vanderbilt.edu

Our lab studies how signaling controls cell identity in healthy human tissues and in diseases, including cancer and immune disorders.  Our neuroscience research projects include:

1) quantitative analysis of neural differentiation using single cell measurements of proteins and signaling molecules,

2) dissecting the unique immunology of the human brain stem cell niche in health and disease,

3) creating computational tools to automatically identify normal and malignant neural lineage cell subsets,

4) screening to identify compounds with novel functions in regulating neural and immune cell identity.

The lab’s approach emphasizes combined use of bench and computational single cell techniques.  Dr. Irish trained at Stanford University where he created a new approach to measure signaling in human cells and applied new bench and computational tools to stratify patient clinical risks based on cell signaling biology.  In the last 5 years, the Irish lab at Vanderbilt has published >40 peer-reviewed manuscripts dissecting cell signaling interactions and creating machine learning tools to quantify cell identity.

For more information, please visit the lab website.