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Gene Expression in the Brain

Christine L. Konradi
Professor of Pharmacology
8160 MRB III
615-936-1021 (office)

Dr. Konradi is internationally recognized for her research on gene expression in the brain, especially in relation to the neurotransmitters dopamine and glutamate.  In recent years, she has turned her attention to the study of schizophrenia and bipolar disorder.  She recently identified a novel disease mechanism in patients with bipolar disorder.


Chartoff, EH, Papadopoulou, M, MacDonald, ML, Parsegian, A, Potter, D, Konradi, C, Carlezon, WA. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc
tissue. Mol Pharmacol, 75(3), 704-12, 2009.

Levine, JB, Leeder, AD, Parekkadan, B, Berdichevsky, Y, Rauch, SL, Smoller, JW, Konradi, C, Berthiaume, F, Yarmush, ML. Isolation rearing impairs wound healing and is associated with increased
locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats. Neuroscience, 151(2), 589-603, 2008.

Schroeder, FA, Penta, KL, Matevossian, A, Jones, SR, Konradi, C, Tapper, AR, Akbarian, S. Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase
induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology, 33(12), 2981-92, 2008.

Levine, JB, Youngs, RM, MacDonald, ML, Chu, M, Leeder, AD, Berthiaume, F, Konradi, C. Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels
in the medial prefrontal cortex. Neuroscience, 145(1), 42-55, 2007.

Naydenov, AV, MacDonald, ML, Ongur, D, Konradi, C. Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to
glucose deprivation stress. Arch Gen Psychiatry, 64(5), 555-64, 2007.

Westin, JE, Vercammen, L, Strome, EM, Konradi, C, Cenci, MA. Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1
receptors. Biol Psychiatry, 62(7), 800-10, 2007.

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